Telomere length and body temperature—independent determinants of mammalian longevity?
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چکیده
منابع مشابه
Telomere length and body temperature—independent determinants of mammalian longevity?
WHY DO SPECIES DIFFER IN LIFESPAN AND WHAT ARE THE DETERMINANTS OF THEIR LONGEVITY? Understanding the main factors that determine variation in species longevity may provide a clue into the leading mechanisms of aging and—what is even more important—outline the key targets for longevity-promoting interventions. Comparative studies on longevity in mammals revealed numerous variables that correlat...
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The nematode Caenorhabditis elegans, after completing its developmental stages and a brief reproductive period, spends the remainder of its adult life as an organism consisting exclusively of post-mitotic cells. Here we show that telomere length varies considerably in clonal populations of wild-type worms, and that these length differences are conserved over at least ten generations, suggesting...
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Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization. Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2013
ISSN: 1664-8021
DOI: 10.3389/fgene.2013.00111